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With its mission to contribute to sustainable human development in a culture of peace, underpinned by tolerance, democracy and human rights, UNESCO Bangkok manages a great variety of programmes in the Asia-Pacific region and in the cluster of the “Mekong” countries - Thailand, Myanmar, Lao PDR, Singapore, Viet Nam and Cambodia.
Asia-Pacific Programme of Education for All (APPEAL) promotes literacy, early childhood care and education, primary education and lifelong education.
Asia-Pacific Programme of Educational Innovation for Development (APEID) works on educational innovations for sustainable and human development with focus on the areas of higher education and ICT in Education.
Education Policy and Reform (EPR) supports national policies and reforms in the Education sector and covers the secondary education sector and the technical and vocational education and training.
Education for Sustainable Development (ESD) supports Education stakeholders to face the issues of Climate change and post-conflict and post-disaster situations.

The HIV Coordination, Adolescent Reproductive and School Health (HARSH) manages HIV policies and school health programmes for adolescents in-school and outside.
Assessment, Information Systems, Monitoring and Statistics (AIMS) is the Asia-Pacific Regional Office of the UNESCO Institute for Statistics (UIS) that provides advisory services and technical assistance in information systems and statistics across all sectors of the UNESCO mandate.
Culture (CLT) safeguards the World’s heritage and promotes cultural diversity.
Intergovernmental Oceanographic Commission/Sub-Commission for the Western Pacific, IOC/WESTPAC, implements marine scientific research programmes for the protection of Oceans and coasts.
Communication and Information (CI) promotes Communication Development, Information Society and  Freedom of Expression
Regional Unit for Social and Human Sciences in Asia and the Pacific, RUSHSAP, promotes ethics in scientific fields and dialogue among countries.
Information and Knowledge Management, IKM
, shapes UNESCO's image and raises the Organisation's visibility throughout the Asia-Pacific region by media and communications work, publications and by managing the office’s website.